|
KMID : 0438219770140010125
|
|
Korea University Medical Journal
1977 Volume.14 No. 1 p.125 ~ p.132
|
|
|
Effect of β-Adrenergic Agent on Water Diuresis
|
|
李世圭/Lee, Sei Kyu
洪淳國/Hong, Soon Kuk
|
|
|
Abstract
|
|
|
The infusion of isoproterenol has been shown to decrease urine volume and free water clearance without altering glomerular filtration rate and without altering or moderately increasing renal plasma flow. It was reported that isoproterenol increase water permeability on toad bladder by similar action of antidiuretic hormone. Recent findings that increased water permeability induced by isoproterenol was inhibited by propranoloL but not by antidiuretic hormone indicate that renal beta adrenergic receptors mediate the increase of water permeability induced by isoproterenol.
It was well recognised that norepinephrine, the principal endogenous alpha adrenergic agent, produces constriction of renal arteries and vasa recta. It was also showed that in kidneys vasodilated with acetylcholine infusion of norepinephrine caused natriuresis while on the opposite, nonvasodilated kidney, sodium excretion decreased. Constriction of vasa recta reserve the medullary osmotic gradient and renal concentrating ability, on the contrary dilation of vasa recta abolish the medullary osmotic gradient and renal concentrating ability.
The present study was designed to examine the effects of isoproterenol on renal function in the rabbit and to determine if these effects are related to changes in renal hemodynamics.
On experiments 20 rabbits were infused with 2.5% dextrose solution until water diuresis were maintained and thereafter simultaneous administration of isuprel (0. 1pg/kg/min), and then isuprel (a 1pg/kg/min) plus noradrenalin (0.5pg/kg/min) were performed. During experiments urine
volum4p, CiN, COSm, CH20, sodium excretion and CPAH, EPAH, RPF, FF, NCPF were measured for
four consecutive specimens every twenty minutes intervals.
The results were as follows:
1) Total renal plasma flow, cortical plasma flow, filtration fraction and medullary plasma flow were not altered by administration of water, isuprel and noradrenalin.
2)´Water diuresis was inhibited by isuprel, while isuprel antidiuresis was inhibited by noradrenalin.
3) Glomerular filtration rate, osmolar clearance and sodium excretion were not altered by water i loading, isuprel and noradrenalin.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|